MovDisordV3, Main, Exploration, bibRecord, 002239

LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han‐Chinese from mainland China

Identifieur interne : 002239 ( Main/Exploration ); précédent : 002238; suivant : 002240

LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han‐Chinese from mainland China

Source :

Movement Disorders [ 0885-3185 ] ; 2009-10-15.

RBID : ISTEX:A255167848BD3478542662FCEE09D2BF04BDED59

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Arginine (genetics), Asian Continental Ancestry Group (ethnology), DNA Mutational Analysis (methods), Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, LRRK2, Male, Middle Aged, Mutation (genetics), Parkinson Disease (genetics), Parkinson's disease, Proline (genetics), Protein-Serine-Threonine Kinases (genetics), R1628P, Young Adult, variant.
MESH :
- chemical , genetics : Arginine, Proline, Protein-Serine-Threonine Kinases.
- ethnology : Asian Continental Ancestry Group.
- genetics : Mutation, Parkinson Disease.
- methods : DNA Mutational Analysis.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Young Adult.

Abstract

Mutations in LRRK2, the gene that encodes leucine‐rich repeat kinase 2 (LRRK2), are associated with autosomal dominant and sporadic forms of Parkinson's disease (PD) and are the most common genetic causes of PD. Recently, a R1628P variant has been reported as a risk factor for PD in Taiwan and Singapore. To determine the association of this variant and PD in the Han‐Chinese population from mainland China, we analyzed its frequency in a cohort of 600 patients and 459 unrelated healthy controls. Forty (6.7%) patients were heterozygous and 3 (0.5%) homozygous for the R1628P variant, which was significantly more frequent than in the controls [2.4% heterozygous and 0.0% homozygous, Odds ratio = 3.14, 95%CI: 1.60–6.17, P < 0.01]. Considering the age at onset, this difference was found only in late‐onset PD (older than 50) [Odds ratio = 3.76, 95% CI: 1.90–7.45, P < 0.01]. Our data confirms that the LRRK2 R1628P variant is associated with an increased risk to develop late onset PD in the ethnic Han‐Chinese population. © 2009 Movement Disorder Society

Url:

https://api.istex.fr/document/A255167848BD3478542662FCEE09D2BF04BDED59/fulltext/pdf

DOI: 10.1002/mds.22371

Affiliations:

Le document en format XML

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<author><name sortKey="Zhang, Zijuan" sort="Zhang, Zijuan" uniqKey="Zhang Z" first="Zijuan" last="Zhang">Zijuan Zhang</name>
</author>
<author><name sortKey="Burgunder, Jean Arc" sort="Burgunder, Jean Arc" uniqKey="Burgunder J" first="Jean-Marc" last="Burgunder">Jean-Marc Burgunder</name>
</author>
<author><name sortKey="An, Xingkai" sort="An, Xingkai" uniqKey="An X" first="Xingkai" last="An">Xingkai An</name>
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<author><name sortKey="Wu, Yan" sort="Wu, Yan" uniqKey="Wu Y" first="Yan" last="Wu">Yan Wu</name>
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<author><name sortKey="Chen, Wenjun" sort="Chen, Wenjun" uniqKey="Chen W" first="Wenjun" last="Chen">Wenjun Chen</name>
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<author><name sortKey="Zhang, Jinhong" sort="Zhang, Jinhong" uniqKey="Zhang J" first="Jinhong" last="Zhang">Jinhong Zhang</name>
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<author><name sortKey="Wang, Yingcheng" sort="Wang, Yingcheng" uniqKey="Wang Y" first="Yingcheng" last="Wang">Yingcheng Wang</name>
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<author><name sortKey="Xu, Yanming" sort="Xu, Yanming" uniqKey="Xu Y" first="Yanming" last="Xu">Yanming Xu</name>
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<author><name sortKey="Gou, Yingru" sort="Gou, Yingru" uniqKey="Gou Y" first="Yingru" last="Gou">Yingru Gou</name>
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<author><name sortKey="Yuan, Guanggu" sort="Yuan, Guanggu" uniqKey="Yuan G" first="Guanggu" last="Yuan">Guanggu Yuan</name>
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<author><name sortKey="Mao, Xueye" sort="Mao, Xueye" uniqKey="Mao X" first="Xueye" last="Mao">Xueye Mao</name>
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<affiliation wicri:level="4"><country xml:lang="fr">Suisse</country>
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<author><name sortKey="An, Xingkai" sort="An, Xingkai" uniqKey="An X" first="Xingkai" last="An">Xingkai An</name>
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<author><name sortKey="Zhang, Jinhong" sort="Zhang, Jinhong" uniqKey="Zhang J" first="Jinhong" last="Zhang">Jinhong Zhang</name>
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<author><name sortKey="Wang, Yingcheng" sort="Wang, Yingcheng" uniqKey="Wang Y" first="Yingcheng" last="Wang">Yingcheng Wang</name>
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<author><name sortKey="Xu, Yanming" sort="Xu, Yanming" uniqKey="Xu Y" first="Yanming" last="Xu">Yanming Xu</name>
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<author><name sortKey="Yuan, Guanggu" sort="Yuan, Guanggu" uniqKey="Yuan G" first="Guanggu" last="Yuan">Guanggu Yuan</name>
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<author><name sortKey="Mao, Xueye" sort="Mao, Xueye" uniqKey="Mao X" first="Xueye" last="Mao">Xueye Mao</name>
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<term>Asian Continental Ancestry Group (ethnology)</term>
<term>DNA Mutational Analysis (methods)</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>LRRK2</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Mutations in LRRK2, the gene that encodes leucine‐rich repeat kinase 2 (LRRK2), are associated with autosomal dominant and sporadic forms of Parkinson's disease (PD) and are the most common genetic causes of PD. Recently, a R1628P variant has been reported as a risk factor for PD in Taiwan and Singapore. To determine the association of this variant and PD in the Han‐Chinese population from mainland China, we analyzed its frequency in a cohort of 600 patients and 459 unrelated healthy controls. Forty (6.7%) patients were heterozygous and 3 (0.5%) homozygous for the R1628P variant, which was significantly more frequent than in the controls [2.4% heterozygous and 0.0% homozygous, Odds ratio = 3.14, 95%CI: 1.60–6.17, P < 0.01]. Considering the age at onset, this difference was found only in late‐onset PD (older than 50) [Odds ratio = 3.76, 95% CI: 1.90–7.45, P < 0.01]. Our data confirms that the LRRK2 R1628P variant is associated with an increased risk to develop late onset PD in the ethnic Han‐Chinese population. © 2009 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han‐Chinese from mainland China

LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han‐Chinese from mainland China

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.